Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children.

AIDS (London, England) - 27 Mar 2012

Freguja Riccardo, Gianesin Ketty, Del Bianco Paola, Malacrida Sandro, Rampon Osvalda, Zanchetta Marisa, Giaquinto Carlo, De Rossi Anita

Abstract excerpt

Toll-like receptors (TLRs) and defensins (DEFs) play a crucial role in the host's innate immunity and may influence HIV-1 disease progression. We investigated the impact of TLR9 +1174G > A, 1635A > G and DEFβ1 -44C > G, -52G > A single nucleotide polymorphisms on the clinical outcome of 95 HIV-1-infected children. The TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Defensins
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Immunity, Innate

Share to Infant

Share to Infant, Newborn

Share to Toll-Like Receptor 9

Source

Identifiers

PMID: 22269973
DOI: 10.1097/QAD.0b013e3283514350

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children.PMID 22269973Read ↗

Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1.Semantic proximity Read ↗

Role of beta-defensin-1 polymorphisms in mother-to-child transmission of HIV-1.Semantic proximity Read ↗

Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.Semantic proximity Read ↗

Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression.Semantic proximity Read ↗

DEFB1 5'UTR polymorphisms modulate the risk of HIV-1 infection in Mexican women.Semantic proximity Read ↗

Strong Association of the rs4986790 Single Nucleotide Polymorphism (SNP) of the Toll-Like Receptor 4 (TLR4) Gene with Human Immunodeficiency Virus (HIV) Infection: A Meta-Analysis.Semantic proximity Read ↗

An assessment of toll-like receptor 7 and 8 gene polymorphisms with susceptibility to HIV-1 infection, AIDS development and response to antiretroviral therapy.Semantic proximity Read ↗

Effects of Interleukin-10 -1082G/A and -592C/A Gene Polymorphisms on the Risk of Human Immunodeficiency Virus-1 Infection: An Updated Meta-analysis.Semantic proximity Read ↗

Cross-talk between virus and host innate immunity in pediatric HIV-1 infection and disease progression.Semantic proximity Read ↗

TRIM5α 136Q, CCR5 Promoter 59029G And CCR264I Alleles Impact The Progression Of HIV In Children And AdolescentsSemantic proximity Read ↗

Defensin gene variation and HIV/AIDS: a comprehensive perspective needed.Semantic proximity Read ↗

Influence of genetic variability in toll-like receptors (TLR 2, TLR 4, and TLR 9) on human immunodeficiency virus-1 disease progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.