Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice.

doi:10.1016/j.mrgentox.2004.04.003

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Article

Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice.

Mutation research - 11 Jul 2004

Mittelstaedt Roberta A, Mei Nan, Webb Peggy J, Shaddock Joseph G, Dobrovolsky Vasily N, McGarrity Lynda J, Morris Suzanne M, Chen Tao, Beland Frederick A, Greenlees Kevin J, Heflich Robert H

Abstract excerpt

Malachite green, a triphenylmethane dye used in aquaculture as an antifungal agent, is rapidly reduced in vivo to leucomalachite green. Previous studies in which female B6C3F1 mice were fed malachite green produced relatively high levels of liver DNA adducts after 28 days, but no significant induction of liver tumors was detected in a 2-year feeding study. Comparable experiments conducted with leucomalachite...

Topics

Analysis of Variance
Aniline Compounds
Animals
Base Sequence
DNA Adducts
Erythrocytes
Female
Liver
Lymphocytes
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Micronuclei, Chromosome-Defective

Mutagenicity Tests

Mutation

Rosaniline Dyes

Time Factors

Transcription Factors

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 15238237
DOI: 10.1016/j.mrgentox.2004.04.003

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