Article
In vivo mutagenicity of conazole fungicides correlates with tumorigenicity.
Mutagenesis - 1 Mar 2009
Ross Jeffrey A, Moore Tanya, Leavitt Sharon A
Abstract excerpt
Triadimefon, propiconazole and myclobutanil are conazoles, an important class of agricultural and therapeutic fungicides. Triadimefon and propiconazole are mouse liver tumorigens, while myclobutanil is not. All three conazoles are generally inactive in short-term genotoxicity tests. We studied the in vivo mutagenicity of these three conazoles using the Big Blue mouse assay system. Groups of mice were fed either...
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