Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.

Mutation research - 22 Jun 2000

Itoh T, Suzuki T, Nishikawa A, Furukawa F, Takahashi M, Xue W, Sofuni T, Hayashi M

Abstract excerpt

2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), a heterocyclic amine found in cooked meat, is a strong mutagen in the Salmonella/microsome assay and was proven to be a hepatocarcinogen in rodents. We used the lacI transgenic (Big Blue(R)) mouse to investigate MeIQx genotoxicity in vivo. lacI mutant frequencies were examined in liver and colon after single intragastric administration of MeIQx (males) or 12...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Colon
Share to Lac Repressors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Micronuclei, Chromosome-Defective

Share to Micronucleus Tests

Share to Mutagenicity Tests

Share to Quinoxalines

Share to Reticulocytes

Source

Identifiers

PMID: 10863154
DOI: 10.1016/s1383-5718(00)00036-x

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.PMID 10863154Read ↗

Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice.Semantic proximity Read ↗

Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.Semantic proximity Read ↗

LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences.Semantic proximity Read ↗

DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue mice does not correlate with mutagenicity.Semantic proximity Read ↗

Genotoxicity of 3-methylcholanthrene in liver of transgenic big Blue mice.Semantic proximity Read ↗

Mutational analysis of the liver, colon and kidney of Big Blue rats treated with 2-amino-3-methylimidazo[4,5-f]quinoline.Semantic proximity Read ↗

In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate.Semantic proximity Read ↗

Hepatic lacI and cII mutation in transgenic (lambdaLIZ) rats treated with dimethylnitrosamine.Semantic proximity Read ↗

Enhanced liver cell mutations in trematode-infected Big Blue transgenic mice.Semantic proximity Read ↗

Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.Semantic proximity Read ↗

Hepatocarcinogen quinoline induces G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (MutaMouse).Semantic proximity Read ↗

Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue transgenic mouse mutation assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.