Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice.

Environmental and molecular mutagenesis - 1 Jun 2014

Cao Xuefei, Mittelstaedt Roberta A, Pearce Mason G, Allen Bruce C, Soeteman-Hernández Lya G, Johnson George E, Bigger C Anita H, Heflich Robert H

Abstract excerpt

The assumption that mutagens have linear dose-responses recently has been challenged. In particular, ethyl methanesulfonate (EMS), a DNA-reactive mutagen and carcinogen, exhibited sublinear or thresholded dose-responses for LacZ mutation in transgenic Muta™Mouse and for micronucleus (MN) frequency in CD1 mice (Gocke E and Müller L [2009]: Mutat Res 678:101-107). In order to explore variables in establishing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ethyl Methanesulfonate
Share to Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lac Operon

Share to Micronucleus Tests

Share to Mutagens

Share to Mutation Rate

Share to Pentosyltransferases

Share to Reticulocytes

Source

Identifiers

PMID: 24535894
DOI: 10.1002/em.21854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice.PMID 24535894Read ↗

Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay.Semantic proximity Read ↗

N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations.Semantic proximity Read ↗

Target organ and time-course in the mutagenicity of five carcinogens in MutaMouse: a summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS.Semantic proximity Read ↗

Combined assessment of transgenic rodent gene mutation and micronuclei formation by benzo[a]pyrene, N-ethyl-N-nitrosourea, 2,4-diaminotoluene and ethyl carbamate.Semantic proximity Read ↗

Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats.Semantic proximity Read ↗

Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay.Semantic proximity Read ↗

Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo.Semantic proximity Read ↗

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies.Semantic proximity Read ↗

Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.Semantic proximity Read ↗

DNA adducts, mutant frequencies and mutation spectra in lambda lacZ transgenic mice treated with N-nitrosodimethylamine.Semantic proximity Read ↗

Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.Semantic proximity Read ↗

Gene-mutation assays in lambda lacZ transgenic mice: comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.