Article
Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue transgenic mouse mutation assay.
Environmental and molecular mutagenesis - 1 Jan 1996
Suter W, Ahiabor R, Blanco B, Locher F, Mantovani F, Robinson M, Sreenan G, Staedtler F, Swingler T, Vignutelli A, Perentes E
Abstract excerpt
Three genotoxic mouse carcinogens, 4-chloro-o-phenylenediamine (4-C-o-PDA), 2-nitro-p-phenylenediamine (2-N-p-PDA), and 2,4-diaminotoluene (2,4-DAT), were tested in the Big Blue transgenic mouse mutation assay. Each experiment consisted of a vehicle control group with ten Big Blue C57BL/6 mice, five of either sex, and an equally sized group treated with a high dose of the test chemical. In addition, four animals...
Topics
- Animals
- Bacterial Proteins
- Bromodeoxyuridine
- Carcinogens
- Cell Division
- Dose-Response Relationship, Drug
- Escherichia coli Proteins
- Female
- Lac Repressors
- Liver