Hepatic gene mutations induced in Big Blue rats by both the potent rat liver azo-carcinogen 6BT and its reported noncarcinogenic analogue 5BT.

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Article

Hepatic gene mutations induced in Big Blue rats by both the potent rat liver azo-carcinogen 6BT and its reported noncarcinogenic analogue 5BT.

Environmental and molecular mutagenesis - 1 Jan 1999

Fletcher K, Soames A R, Tinwell H, Lefevre P A, Ashby J

Abstract excerpt

The potent rat liver carcinogen 6-p-dimethylaminophenylazobenzthiazole (6BT) and its reported noncarcinogenic analogue 5-p-dimethylaminophenylazobenzthiazole (5BT; evaluated for carcinogenicity under the similar limited bioassay conditions used for 6BT) have been studied in order to seek an explanation for their different carcinogenic activities. Both compounds act as DNA-damaging agents to the rat liver, and...

Topics

Animals
Benzothiazoles
Carcinogens
Cell Division
Liver
Liver Neoplasms, Experimental
Male
Mutation
Rats
Thiazoles
p-Dimethylaminoazobenzene

Source

Open in PubMed

Identifiers

PMID: 10529739

Provenance

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