Article
Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.
Mutation research - 10 Nov 2003
Masumura Ken-ichi, Horiguchi Mieko, Nishikawa Akiyoshi, Umemura Takashi, Kanki Keita, Kanke Yusuke, Nohmi Takehiko
Abstract excerpt
Although humans are chronically exposed to most environmental chemicals at low doses, genotoxicity assays with rodents are usually performed at high doses with short treatment period. To investigate the dose-response of genotoxicity at lower doses, gpt delta transgenic mice were fed a diet containing 300, 30 or 3 parts per million (ppm) of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) for 12 weeks and the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.