Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromium(VI)-induced mutagenesis in the lungs of big blue transgenic mice.

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer - 1 Jan 2000

Cheng L, Sonntag D M, de Boer J, Dixon K

Abstract excerpt

The mutagenic activity of the hexavalent chromium [Cr(VI)] compound potassium dichromate was examined in the Big Blue transgenic mouse lung, the target organ for Cr(VI) carcinogenesis in humans. Mice were exposed to Cr(VI) by intratracheal instillation of a potassium dichromate (K2Cr2O7) solution. Analysis of the deposition of Cr in mouse lungs revealed that the procedure reproducibly resulted in about 5%...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites
Share to Carcinogens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione

Share to Kidney

Share to Mutagenesis

Share to Mutagens

Share to Trachea

Source

Identifiers

PMID: 10983890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromium(VI)-induced mutagenesis in the lungs of big blue transgenic mice.PMID 10983890Read ↗

Clastogenicity and mutagenicity of hexavalent chromium in lacZ transgenic mice.Semantic proximity Read ↗

Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks.Semantic proximity Read ↗

Organ-targeted mutagenicity of nitrofurantoin in Big Blue transgenic mice.Semantic proximity Read ↗

2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.Semantic proximity Read ↗

Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types.Semantic proximity Read ↗

Genotoxicity of 3-methylcholanthrene in liver of transgenic big Blue mice.Semantic proximity Read ↗

Spontaneous mutation frequency and pattern in Big Blue mice fed a vitamin E-supplemented diet.Semantic proximity Read ↗

Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment.Semantic proximity Read ↗

A more efficient Big Blue protocol improves transgene rescue and accuracy in a adduct and mutation measurement.Semantic proximity Read ↗

Target organ and time-course in the mutagenicity of five carcinogens in MutaMouse: a summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS.Semantic proximity Read ↗

Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water.Semantic proximity Read ↗

Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.