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Genotoxicity of 3-methylcholanthrene in liver of transgenic big Blue mice.

Environmental and molecular mutagenesis - 1 Jan 2000

Rihn B H, Bottin M C, Coulais C, Rouget R, Monhoven N, Baranowski W, Edorh A, Keith G

Abstract excerpt

Transgenic mice provide a unique tool for studying the tissue specificity and mutagenic potential of chemicals. Because 3-methylcholanthrene (3MC) was found mutagenic in bacteria, clastogenic in bone marrow, and induces DNA adducts in animals, we were interested to determinine whether this xenobiotic provokes (1) cell proliferation, (2) transcriptional activity changes, (3) DNA adducts, and (4) hepatic mutations...

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PMID: 11152559
DOI: 10.1002/1098-2280(2000)36:4<266::aid-em2>3.0.co;2-h

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