Genotoxicity of 3-methylcholanthrene in liver of transgenic big Blue mice.

doi:10.1002/1098-2280(2000)36:4<266::aid-em2>3.0.co;2-h

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Article

Genotoxicity of 3-methylcholanthrene in liver of transgenic big Blue mice.

Environmental and molecular mutagenesis - 1 Jan 2000

Rihn B H, Bottin M C, Coulais C, Rouget R, Monhoven N, Baranowski W, Edorh A, Keith G

Abstract excerpt

Transgenic mice provide a unique tool for studying the tissue specificity and mutagenic potential of chemicals. Because 3-methylcholanthrene (3MC) was found mutagenic in bacteria, clastogenic in bone marrow, and induces DNA adducts in animals, we were interested to determinine whether this xenobiotic provokes (1) cell proliferation, (2) transcriptional activity changes, (3) DNA adducts, and (4) hepatic mutations...

Topics

Animals
Bacterial Proteins
Base Sequence
Cell Division
DNA Adducts
DNA Primers
Escherichia coli Proteins
Lac Repressors
Liver
Methylcholanthrene
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutagens
Mutation
Organ Size
Repressor Proteins

Source

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Identifiers

PMID: 11152559
DOI: 10.1002/1098-2280(2000)36:4<266::aid-em2>3.0.co;2-h

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