Article
Analysis of mutations and bone marrow micronuclei in Big Blue rats fed leucomalachite green.
Mutation research - 22 Mar 2004
Manjanatha M G, Shelton S D, Bishop M, Shaddock J G, Dobrovolsky V N, Heflich R H, Webb P J, Blankenship L R, Beland F A, Greenlees K J, Culp S J
Abstract excerpt
Leucomalachite green (LMG) is the major metabolite of malachite green (MG), a triphenylmethane dye that has been used widely as an antifungal agent in the fish industry. Concern over MG and LMG is due to the potential for consumer exposure, suggestive evidence of tumor promotion in rodent liver, and suspicion of carcinogenicity based on structure-activity relationships. In order to evaluate the risks associated...
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