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Article

Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.

Molecular and cellular biology - 1 May 2008

Sustmann Claudio, Flach Henrik, Ebert Hanna, Eastman Quinn, Grosschedl Rudolf

Abstract excerpt

Transcriptional regulation by the canonical Wnt pathway involves the stabilization and nuclear accumulation of beta-catenin, which assembles with LEF1/TCF transcription factors and cofactors to activate Wnt target genes. Recently, the nuclear beta-catenin complex has been shown to contain BCL9, which interacts with beta-catenin and recruits Pygopus as a transcriptional coactivator. However, the presumed general...

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Source

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Identifiers

PMID: 18347063
DOI: 10.1128/MCB.01986-07
PMCID: PMC2423143

Genes

BCL9
TRRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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