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Article

Identification and in vivo role of the Armadillo-Legless interaction.

Development (Cambridge, England) - 1 Sept 2004

Hoffmans Raymond, Basler Konrad

Abstract excerpt

The Wnt signalling system controls many fundamental processes during animal development and its deregulation has been causally linked to colorectal cancer. Transduction of Wnt signals entails the association of beta-catenin with nuclear TCF DNA-binding factors and the subsequent activation of target genes. Using genetic assays in Drosophila, we have recently identified a presumptive adaptor protein, Legless...

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PMID: 15294866
DOI: 10.1242/dev.01296

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification and in vivo role of the Armadillo-Legless interaction.PMID 15294866Read ↗

Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.Semantic proximity Read ↗

Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins.Semantic proximity Read ↗

Pygopus residues required for its binding to Legless are critical for transcription and development.Semantic proximity Read ↗

A new nuclear component of the Wnt signalling pathway.Semantic proximity Read ↗

The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3.Semantic proximity Read ↗

Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.Semantic proximity Read ↗

A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.Semantic proximity Read ↗

Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.Semantic proximity Read ↗

Drosophila Wnt/Fz pathways.Semantic proximity Read ↗

An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling.Semantic proximity Read ↗

The armadillo family of structural proteins.Semantic proximity Read ↗

Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.Semantic proximity Read ↗

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