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Article

Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.

Nature - 24 Apr 2003

Takemaru Ken-Ichi, Yamaguchi Shinji, Lee Young Sik, Zhang Yang, Carthew Richard W, Moon Randall T

Abstract excerpt

Inappropriate activation of downstream target genes by the oncoprotein beta-catenin is implicated in development of numerous human cancers. beta-catenin and its fruitfly counterpart Armadillo act as a coactivator in the canonical Wnt/Wingless pathway by binding to Tcf/Lef transcription factors. Here we report a conserved nuclear protein, named Chibby, which was identified in a screen for proteins that directly...

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Identifiers

PMID: 12712206
DOI: 10.1038/nature01570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.PMID 12712206Read ↗

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Chibby, an Antagonist of the Wnt/β-Catenin Pathway, Facilitates Cardiomyocyte Differentiation of Murine Embryonic Stem CellsSemantic proximity Read ↗

A nuclear function for armadillo/beta-catenin.Semantic proximity Read ↗

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.Semantic proximity Read ↗

A new nuclear component of the Wnt signalling pathway.Semantic proximity Read ↗

Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.Semantic proximity Read ↗

TCF transcription factors: molecular switches in carcinogenesis.Semantic proximity Read ↗

A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.Semantic proximity Read ↗

Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines.Semantic proximity Read ↗

Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development.Semantic proximity Read ↗

Wnt target genes and where to find themSemantic proximity Read ↗

Identification and in vivo role of the Armadillo-Legless interaction.Semantic proximity Read ↗

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