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Article

A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2008

Mieszczanek Juliusz, de la Roche Marc, Bienz Mariann

Abstract excerpt

Wnt/beta-catenin signaling controls animal development and tissue homeostasis, and is also an important cancer pathway. Pygopus (Pygo) is a conserved nuclear Wnt signaling component that is essential for Wingless-induced transcription throughout Drosophila development. It associates with Armadillo/beta-catenin and T cell factor (TCF) through the Legless/BCL9 adaptor, but its molecular function in TCF-mediated...

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Identifiers

PMID: 19036929
DOI: 10.1073/pnas.0806098105
PMCID: PMC2614760

Genes

BCL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.PMID 19036929Read ↗

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Pygopus residues required for its binding to Legless are critical for transcription and development.Semantic proximity Read ↗

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.Semantic proximity Read ↗

Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins.Semantic proximity Read ↗

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The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3.Semantic proximity Read ↗

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