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Article

Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins.

Mechanisms of development - 1 Nov 2005

Städeli Reto, Basler Konrad

Abstract excerpt

Members of the Wingless (Wg)/Wnt family of secreted glycoproteins control cell fate during embryonic development and adult homeostasis. Wnt signals regulate the expression of target genes by activating a conserved signal transduction pathway. Upon receptor activation, the signal is transmitted intracellularly by stabilization of Armadillo (Arm)/beta-catenin. Arm/beta-catenin translocates to the nucleus, interacts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16169192
DOI: 10.1016/j.mod.2005.07.004

Genes

BCL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins.PMID 16169192Read ↗

Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.Semantic proximity Read ↗

Pygopus residues required for its binding to Legless are critical for transcription and development.Semantic proximity Read ↗

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A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.Semantic proximity Read ↗

A new nuclear component of the Wnt signalling pathway.Semantic proximity Read ↗

The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3.Semantic proximity Read ↗

Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan.Semantic proximity Read ↗

pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila.Semantic proximity Read ↗

Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis.Semantic proximity Read ↗

Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.Semantic proximity Read ↗

The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled.Semantic proximity Read ↗

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