Article
An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.
The International journal of developmental biology - 1 Jan 2007
Looman Camilla, Sun Tong, Yu Yang, Zieba Agata, Ahgren Aive, Feinstein Ricardo, Forsberg Henrik, Hellberg Carina, Heldin Carl-Henrik, Zhang Xiao-Qun, Forsberg-Nilsson Karin, Khoo Nelson, Fundele Reinald, Heuchel Rainer
Abstract excerpt
An oncogenic D842V mutation in the platelet-derived growth factor (PDGF) alpha-receptor (Pdgfra) has recently been described in patients with gastrointestinal stromal tumors. In order to test if the same mutation would confer oncogenic properties to the homologous PDGF beta-receptor (Pdgfrb), the corresponding aspartic acid residue at position 849 of Pdgfrb was changed into valine (D849V) using a knock-in...
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