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Article

Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.

The Journal of biological chemistry - 11 Mar 2005

Gao Zhiyang, Sasaoka Toshiyasu, Fujimori Toshihiko, Oya Takeshi, Ishii Yoko, Sabit Hemragul, Kawaguchi Makoto, Kurotaki Yoko, Naito Maiko, Wada Tsutomu, Ishizawa Shin, Kobayashi Masashi, Nabeshima Yo-Ichi, Sasahara Masakiyo

Abstract excerpt

This study provides new perspectives of the unique aspects of platelet-derived growth factor beta-receptor (PDGFR-beta) signaling and biological responses through the establishment of a mutant mouse strain in which two loxP sequences were inserted into the introns of PDGFR-beta genome sequences. Isolation of skin fibroblasts from the mutant mice and Cre recombinase transfection in vitro induced PDGFR-beta gene...

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Source

Identifiers

PMID: 15590688
DOI: 10.1074/jbc.M413081200

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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