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Article

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.

Developmental cell - 1 Feb 2009

Olson Lorin E, Soriano Philippe

Abstract excerpt

PDGF signaling regulates the development of mesenchymal cell types in the embryo and in the adult, but the role of receptor activation in tissue homeostasis has not been investigated. We have generated conditional knockin mice with mutations in PDGFRalpha that drive increased kinase activity under the control of the endogenous PDGFRalpha promoter. In embryos, increased PDGFRalpha signaling leads to hyperplasia of...

Topics

Animals
Cell Proliferation
Connective Tissue
Female
Fibroblasts
Fibrosis
Homeostasis
Lung
Mice
Mice, Transgenic
Models, Biological
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptor, Platelet-Derived Growth Factor alpha

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 19217431
DOI: 10.1016/j.devcel.2008.12.003
PMCID: PMC2664622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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