Article
An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development.
Developmental cell - 1 Jan 2002
Klinghoffer Richard A, Hamilton T Guy, Hoch Renée, Soriano Philippe
Abstract excerpt
A central issue in signal transduction is the physiological contribution of different growth factor-initiated signaling pathways. We have generated knockin mice harboring mutations in the PDGFalpha receptor (PDGFalphaR) that selectively eliminate its capacity to activate PI3 kinase (alpha(PI3K)) or Src family kinases (alpha(Src)). The alpha(PI3K) mutation leads to neonatal lethality due to impaired signaling in...
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