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Article

Involvement of mammalian Mus81 in genome integrity and tumor suppression.

Science (New York, N.Y.) - 18 Jun 2004

McPherson John Peter, Lemmers Bénédicte, Chahwan Richard, Pamidi Ashwin, Migon Eva, Matysiak-Zablocki Elzbieta, Moynahan Mary Ellen, Essers Jeroen, Hanada Katsuhiro, Poonepalli Anuradha, Sanchez-Sweatman Otto, Khokha Rama, Kanaar Roland, Jasin Maria, Hande M Prakash, Hakem Razqallah

Abstract excerpt

Mus81-Eme1 endonuclease has been implicated in the rescue of stalled replication forks and the resolution of meiotic recombination intermediates in yeast. We used gene targeting to study the physiological requirements of Mus81 in mammals. Mus81-/- mice are viable and fertile, which indicates that mammalian Mus81 is not essential for recombination processes associated with meiosis. Mus81-deficient mice and cells...

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Identifiers

PMID: 15205536
DOI: 10.1126/science.1094557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Involvement of mammalian Mus81 in genome integrity and tumor suppression.PMID 15205536Read ↗

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MUS81-EME2 Promotes Replication Fork RestartSemantic proximity Read ↗

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The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together.Semantic proximity Read ↗

Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.Semantic proximity Read ↗

The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability.Semantic proximity Read ↗

Mus81 is essential for sister chromatid recombination at broken replication forks.Semantic proximity Read ↗

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Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.Semantic proximity Read ↗

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