Article
Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility.
Genes & development - 1 Mar 2003
Wei Kaichun, Clark Alan B, Wong Edmund, Kane Michael F, Mazur Dan J, Parris Tchaiko, Kolas Nadine K, Russell Robert, Hou Harry, Kneitz Burkhard, Yang Guohze, Kunkel Thomas A, Kolodner Richard D, Cohen Paula E, Edelmann Winfried
Abstract excerpt
Exonuclease 1 (Exo1) is a 5'-3' exonuclease that interacts with MutS and MutL homologs and has been implicated in the excision step of DNA mismatch repair. To investigate the role of Exo1 in mammalian mismatch repair and assess its importance for tumorigenesis and meiosis, we generated an Exo1 mutant mouse line. Analysis of Exo1(-/-) cells for mismatch repair activity in vitro showed that Exo1 is required for the...
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