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Article

EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.

Nucleic acids research - 3 Sept 2015

Rein Katrin, Yanez Diana A, Terré Berta, Palenzuela Lluís, Aivio Suvi, Wei Kaichun, Edelmann Winfried, Stark Jeremy M, Stracker Travis H

Abstract excerpt

The maintenance of genome stability is critical for the suppression of diverse human pathologies that include developmental disorders, premature aging, infertility and predisposition to cancer. The DNA damage response (DDR) orchestrates the appropriate cellular responses following the detection of lesions to prevent genomic instability. The MRE11 complex is a sensor of DNA double strand breaks (DSBs) and plays...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26160886
DOI: 10.1093/nar/gkv691
PMCID: PMC4551929

Genes

EXO1
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.PMID 26160886Read ↗

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