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Article

A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.

Nucleic acids research - 1 Nov 2013

Fadden Andrew J, Schalbetter Stephanie, Bowles Maureen, Harris Richard, Lally John, Carr Antony M, McDonald Neil Q

Abstract excerpt

The MUS81-EME1 endonuclease maintains metazoan genomic integrity by cleaving branched DNA structures that arise during the resolution of recombination intermediates. In humans, MUS81 also forms a poorly characterized complex with EME2. Here, we identify and determine the structure of a winged helix (WH) domain from human MUS81, which binds DNA. WH domain mutations greatly reduce binding of the isolated domain to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23982516
DOI: 10.1093/nar/gkt760
PMCID: PMC3834828

Genes

MUS81
EME2
EME1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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