Article
The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene.
Cell - 8 Sept 1995
Hari K L, Santerre A, Sekelsky J J, McKim K S, Boyd J B, Hawley R S
Abstract excerpt
The D. melanogaster mei-41 gene is required for DNA repair, mitotic chromosome stability, and normal levels of meiotic recombination in oocytes. Here we show that the predicted mei-41 protein is similar in sequence to the ATM (ataxia telangiectasia) protein from humans and to the yeast rad3 and M...
Topics
- Animals
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle
- Cell Cycle Proteins
- Cloning, Molecular
- DNA Damage
- DNA-Binding Proteins
- Drosophila melanogaster
- Genes, Insect
- Humans
- Molecular Sequence Data
- Neurons
- Phenotype
- Phosphotransferases
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Serine-Threonine Kinases
- Proteins