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Article

MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.

PLoS genetics - 12 Sept 2008

Holloway J Kim, Booth James, Edelmann Winfried, McGowan Clare H, Cohen Paula E

Abstract excerpt

Two eukaryotic pathways for processing double-strand breaks (DSBs) as crossovers have been described, one dependent on the MutL homologs Mlh1 and Mlh3, and the other on the structure-specific endonuclease Mus81. Mammalian MUS81 has been implicated in maintenance of genomic stability in somatic cells; however, little is known about its role during meiosis. Mus81-deficient mice were originally reported as being...

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Source

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Identifiers

PMID: 18787696
DOI: 10.1371/journal.pgen.1000186
PMCID: PMC2525838

Genes

MUS81
MLH1
MLH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.PMID 18787696Read ↗

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