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MUS81-EME2 Promotes Replication Fork Restart

1 May 2014

Abstract excerpt

Replication forks frequently stall at regions of the genome that are difficult to replicate or contain lesions that cause replication blockage. An important mechanism for the restart of a stalled fork involves endonucleolytic cleavage that can lead to fork restoration and replication progression. Here, we show that the structure-selective endonuclease MUS81-EME2 is responsible for fork cleavage and restart in...

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Identifiers

PMID: 24813886
DOI: 10.1016/j.celrep.2014.04.007

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