Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.

Molecular cell - 22 Dec 2010

Ho Chu Kwen, Mazón Gerard, Lam Alicia F, Symington Lorraine S

Abstract excerpt

Holliday junction (HJ) resolution is required for segregation of chromosomes and for formation of crossovers during homologous recombination. The identity of the resolvase(s) that functions in vivo has yet to be established, although several proteins able to cut HJs in vitro have been identified as candidates in yeasts and mammals. Using an assay to detect unselected products of mitotic recombination, we found a...

Topics

DNA-Binding Proteins
Endonucleases
Genome, Fungal
Genomic Instability
Holliday Junction Resolvases
Mitosis
Mutation
Recombination, Genetic
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 21172663
DOI: 10.1016/j.molcel.2010.11.016
PMCID: PMC3021384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.PMID 21172663Read ↗

The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.Semantic proximity Read ↗

The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.Semantic proximity Read ↗

The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability.Semantic proximity Read ↗

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.Semantic proximity Read ↗

Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates.Semantic proximity Read ↗

Spatial control of the GEN1 Holliday junction resolvase ensures genome stability.Semantic proximity Read ↗

Single Holliday junctions are intermediates of meiotic recombination.Semantic proximity Read ↗

Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.Semantic proximity Read ↗

The Cdc14 Phosphatase Controls Resolution of Recombination Intermediates and Crossover Formation during Meiosis.Semantic proximity Read ↗

The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.Semantic proximity Read ↗

Holliday junctions in the eukaryotic nucleus: resolution in sight?Semantic proximity Read ↗

Mus81 is essential for sister chromatid recombination at broken replication forks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.