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Article

Mus81 is essential for sister chromatid recombination at broken replication forks.

The EMBO journal - 7 May 2008

Roseaulin Laura, Yamada Yoshiki, Tsutsui Yasuhiro, Russell Paul, Iwasaki Hiroshi, Arcangioli Benoit

Abstract excerpt

Recombination is essential for the recovery of stalled/collapsed replication forks and therefore for the maintenance of genomic stability. The situation becomes critical when the replication fork collides with an unrepaired single-strand break and converts it into a one-ended double-strand break. We show in fission yeast that a unique broken replication fork requires the homologous recombination (HR) enzymes for...

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Identifiers

PMID: 18388861
DOI: 10.1038/emboj.2008.65
PMCID: PMC2374842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mus81 is essential for sister chromatid recombination at broken replication forks.PMID 18388861Read ↗

Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange.Semantic proximity Read ↗

Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.Semantic proximity Read ↗

The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.Semantic proximity Read ↗

A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.Semantic proximity Read ↗

MUS81-EME2 Promotes Replication Fork RestartSemantic proximity Read ↗

Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.Semantic proximity Read ↗

Single Holliday junctions are intermediates of meiotic recombination.Semantic proximity Read ↗

Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.Semantic proximity Read ↗

The novel gene mus7(+) is involved in the repair of replication-associated DNA damage in fission yeast.Semantic proximity Read ↗

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.Semantic proximity Read ↗

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint.Semantic proximity Read ↗

Crystal structure of the Mus81-Eme1 complex.Semantic proximity Read ↗

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