Article
ATP-dependent pre-replicative complex assembly is facilitated by Adk1p in budding yeast.
The Journal of biological chemistry - 24 Sept 2010
Cheng Xue, Xu Zhen, Wang Jiafeng, Zhai Yuanliang, Lu Yongjun, Liang Chun
Abstract excerpt
Pre-replicative complex (pre-RC) assembly is a critical part of the mechanism that controls the initiation of DNA replication, and ATP binding and hydrolysis by multiple pre-RC proteins are essential for pre-RC assembly and activation. Here, we demonstrate that Adk1p (adenylate kinase 1 protein) plays an important role in pre-RC assembly in Saccharomyces cerevisiae. Isolated from a genetic screen, adk1(G20S)...
Topics
- Adenosine Triphosphate
- Adenylyl Cyclases
- Cell Cycle
- Chromatin
- DNA Replication
- DNA, Fungal
- Hot Temperature
- Mutation
- Origin Recognition Complex
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins