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Article

ATP-dependent pre-replicative complex assembly is facilitated by Adk1p in budding yeast.

The Journal of biological chemistry - 24 Sept 2010

Cheng Xue, Xu Zhen, Wang Jiafeng, Zhai Yuanliang, Lu Yongjun, Liang Chun

Abstract excerpt

Pre-replicative complex (pre-RC) assembly is a critical part of the mechanism that controls the initiation of DNA replication, and ATP binding and hydrolysis by multiple pre-RC proteins are essential for pre-RC assembly and activation. Here, we demonstrate that Adk1p (adenylate kinase 1 protein) plays an important role in pre-RC assembly in Saccharomyces cerevisiae. Isolated from a genetic screen, adk1(G20S)...

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Identifiers

PMID: 20659900
DOI: 10.1074/jbc.M110.161455
PMCID: PMC2943264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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