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Article

The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription.

Nucleic acids research - 1 Jan 2005

Nieduszynski Conrad A, Blow J Julian, Donaldson Anne D

Abstract excerpt

The mini-chromosome maintenance proteins Mcm2-7 are essential for DNA replication. They are loaded onto replication origins during G1 phase of the cell cycle to form a pre-replication complex (pre-RC) that licenses each origin for subsequent initiation. We have investigated the DNA elements that determine the dependence of yeast replication origins on Mcm2-7 activity, i.e. the sensitivity of an origin to mcm...

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Identifiers

PMID: 15860777
DOI: 10.1093/nar/gki539
PMCID: PMC1087785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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