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Article

Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations.

Human molecular genetics - 15 Aug 2004

Li Jing, Moran Thomas, Swanson Eric, Julian Christina, Harris Jeremy, Bonen Denise K, Hedl Matija, Nicolae Dan L, Abraham Clara, Cho Judy H

Abstract excerpt

Crohn's disease (CD) is a chronic inflammation affecting the gastrointestinal tract. Three mutations (Arg702Trp, Gly908Arg and Leu1007fsinsC) within the NOD2/CARD15 gene increase CD susceptibility. Here, we define cytokine regulation in primary human mononuclear cells, with muramyl dipeptide (MDP), the minimal NOD2/CARD15 activating component of peptidoglycan. By microarray, MDP induces a broad array of...

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Source

Identifiers

PMID: 15198989
DOI: 10.1093/hmg/ddh182

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations.PMID 15198989Read ↗

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