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Article

Functional interaction of CARD15/NOD2 and Crohn's disease-associated TNFalpha polymorphisms.

International journal of colorectal disease - 1 Jul 2005

Linderson Ylva, Bresso Francesca, Buentke Eva, Pettersson Sven, D'Amato Mauro

Abstract excerpt

BACKGROUND AND AIMS: Mutations/polymorphisms in the CARD15/NOD2 gene and in the promoter region of the TNFalpha gene are associated with susceptibility to and modulate the phenotype of Crohn's disease (CD). The molecular mechanisms for this genotype-phenotype correlation are yet to be elucidated. CARD15 is an intracellular receptor for bacterial muramyl dipeptide (MDP), and can elicit an inflammatory response via...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15800781
DOI: 10.1007/s00384-004-0732-z

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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