Article
Functional consequences of NOD2 (CARD15) mutations.
Inflammatory bowel diseases - 1 Jul 2006
Abraham Clara, Cho Judy H
Abstract excerpt
Polymorphisms in NOD2 (CARD15) are associated with ileal and ileocolonic Crohn's disease, increased mortality from graft-versus-host disease, and Blau syndrome. NOD2 activation by peptidoglycan components initiates various signaling pathways and CD-associated NOD2 mutations are associated with decreased activation of NF-kappaB. NOD2 may be important for both initial defenses against commensal and pathogenic...
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