Article
The molecular basis of NOD2 susceptibility mutations in Crohn's disease.
Mucosal immunology - 1 Nov 2008
Strober W, Kitani A, Fuss I, Asano N, Watanabe T
Abstract excerpt
Nucleotide oligomerization domain (NOD)2 is a member of the NOD-like receptor family of proteins that initiate inflammatory responses when exposed to ligands derived from bacterial components that gain access to the intracellular milieu. It is thus somewhat paradoxical that polymorphisms in the gene that encode NOD2 (CARD15) that lead to impaired NOD2 function, are susceptibility factors in Crohn's disease, a...
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