Article
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
American journal of human genetics - 1 Apr 2002
Lesage Suzanne, Zouali Habib, Cézard Jean-Pierre, Colombel Jean-Frédéric, Belaiche Jacques, Almer Sven, Tysk Curt, O'Morain Colm, Gassull Miquel, Binder Vibeke, Finkel Yigael, Modigliani Robert, Gower-Rousseau Corinne, Macry Jeanne, Merlin Françoise, Chamaillard Mathias, Jannot Anne-Sophie, Thomas Gilles, Hugot Jean-Pierre
Abstract excerpt
CARD15/NOD2 encodes a protein involved in bacterial recognition by monocytes. Mutations in CARD15 have recently been found in patients with Crohn disease (CD), a chronic inflammatory condition of the digestive tract. Here, we report the mutational analyses of CARD15 in 453 patients with CD, including 166 sporadic and 287 familial cases, 159 patients with ulcerative colitis (UC), and 103 healthy control subjects....
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