Article
NOD2 mutations affect muramyl dipeptide stimulation of human B lymphocytes and interact with other IBD-associated genes.
Digestive diseases and sciences - 1 Sept 2013
Lin Zhenwu, Hegarty John P, John Gerrit, Berg Arthur, Wang Zhong, Sehgal Rishabh, Pastor Danielle M, Wang Yunhua, Harris Leonard R, Poritz Lisa S, Schreiber Stefan, Koltun Walter A
Abstract excerpt
BACKGROUND: Genetic and functional studies have associated variants in the NOD2/CARD15 gene with Crohn's disease. AIMS: This study aims to replicate the association of three common NOD2 mutations with Crohn's disease, study its effect on NOD2 expression in B cells and its interaction with other IBD-associated genes. METHODS: A total of 294 IBD patients (179 familial IBD, 115 sporadic IBD) and 298 unrelated...
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