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Article

Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease.

Inflammatory bowel diseases - 1 Jul 2006

van Heel David A, Hunt Karen A, King Kathy, Ghosh Subrata, Gabe Simon M, Mathew Christopher G, Forbes Alastair, Playford Raymond J

Abstract excerpt

BACKGROUND AND AIMS: Crohn's disease is strongly associated with double mutations in NOD2/CARD15. Three common mutations (Arg702Trp, Gly908Arg, Leu1007fs) impair innate immune responses to bacterial muramyl dipeptide. Rare NOD2 variants occur, but it is difficult to both identify them and assess their functional effect. We assessed the true frequency of defective muramyl dipeptide sensing in Crohn's disease and...

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Identifiers

PMID: 16804397
DOI: 10.1097/01.ibd.0000225344.21979.89

Genes

NOD2

Provenance

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Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease.PMID 16804397Read ↗

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