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Article

Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease.

European journal of immunology - 1 Jun 2006

van Heel David A, Hunt Karen A, Ghosh Subrata, Hervé Mireille, Playford Raymond J

Abstract excerpt

Both NOD2/CARD15 alleles are mutated in approximately 10% of Crohn's disease patients, causing loss of functional responses to low-dose muropeptide agonists. We hypothesized that NOD2 mutations may also impair NOD1/CARD4 responses, supported by data suggesting NOD2 1007fs/1007fs patients had reduced responses to a putative NOD1 agonist, diaminopimelic acid-containing muramyl tripeptide (M-TriDAP). We measured...

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Identifiers

PMID: 16637007
DOI: 10.1002/eji.200535636

Genes

NOD2
NOD1
TNF

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