Article
NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes.
Inflammatory bowel diseases - 1 Aug 2008
Beynon Vanessa, Cotofana Sebastian, Brand Stephan, Lohse Peter, Mair Anja, Wagner Stefanie, Mussack Thomas, Ochsenkühn Thomas, Folwaczny Matthias, Folwaczny Christian, Glas Jürgen, Török Helga-Paula
Abstract excerpt
BACKGROUND: The functional link between mutations in NOD2 and Crohn's disease (CD) has not been entirely elucidated. The 1007fs mutation results in loss of NF-kappaB activation in response to muramyl dipeptide (MDP) but has also been linked to an increased IL-1beta processing and IL-12 release. METHODS: We investigated the basal and MDP-triggered mRNA expression and protein release for TNF-alpha, IL-10, IL-1beta,...
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