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Article

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.

Lancet (London, England) - 1 Jan 2000

van Heel David A, Ghosh Subrata, Butler Matt, Hunt Karen A, Lundberg Anna M C, Ahmad Tariq, McGovern Dermot P B, Onnie Clive, Negoro Kenichi, Goldthorpe Sue, Foxwell Brian M J, Mathew Christopher G, Forbes Alastair, Jewell Derek P, Playford Raymond J

Abstract excerpt

Both NOD2 (CARD15) alleles are mutated in roughly 15% of patients with Crohn's disease, but functional effects are unclear. We analysed the cytokine response of peripheral blood mononuclear cells to muramyl dipeptide (MDP), the ligand for NOD2. MDP induced little TNFalpha or interleukin 1beta, but strong interleukin-8 secretion. MDP also substantially upregulated secretion of TNFalpha and interleukin 1beta...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1

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Source

Identifiers

PMID: 15910952
DOI: 10.1016/S0140-6736(05)66582-8

Genes

NOD2

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