Lessons to be learned from the NOD2 gene in Crohn's disease.

Abstract excerpt

The recent discovery that CARD15/NOD2 is involved in the genetic predisposition to Crohn's disease (CD) provides the final demonstration that CD is a genetic disorder. The gene explains about 20% of the genetic susceptibility. CARD15 mutations are present in 30-50% of CD patients compared to 7-20% of healthy controls. Interestingly, CD patients often carry mutations on their two chromosomes suggesting a mutation...

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• Carrier Proteins
• Chromosome Mapping
• Crohn Disease
• DNA Mutational Analysis
• Genetic Predisposition to Disease