Article
Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 May 2004
Nakagami Hironori, Morishita Ryuichi, Nishikawa Tomoyuki, Shimizu Hideo, Iguchi Sota, Matsumoto Kunio, Nakamura Toshikazu, Kaneda Yasufumi, Ogihara Toshio
Abstract excerpt
Bag-1 is a novel multifunctional protein. It was identified based on its ability to bind the anti-apoptotic protein, bcl-2, and also reported to interact with the heat shock protein 70 kDa (Hsp70). Thus, bag-1 may modulate apoptosis and the chaperone activity. More interestingly, bag-1 can bind to several growth factor receptors or steroid hormone receptors and regulate their function and signaling. The receptor...
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