Article
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
Nature neuroscience - 1 Sept 2005
Götz Rudolf, Wiese Stefan, Takayama Shinichi, Camarero Guadalupe C, Rossoll Wilfried, Schweizer Ulrich, Troppmair Jakob, Jablonka Sibylle, Holtmann Bettina, Reed John C, Rapp Ulf R, Sendtner Michael
Abstract excerpt
Bag1 is a cochaperone for the heat-shock protein Hsp70 that interacts with C-Raf, B-Raf, Akt, Bcl-2, steroid hormone receptors and other proteins. Here we use targeted gene disruption in mice to show that Bag1 has an essential role in the survival of differentiating neurons and hematopoietic cells. Cells of the fetal liver and developing nervous system in Bag1-/- mice underwent massive apoptosis. Lack of Bag1 did...
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