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Article

Bag1 Functions In Vivo as a Negative Regulator of Hsp70 Chaperone Activity

1 Feb 2000

Abstract excerpt

Studies on the Hsp70 chaperone machine in eukaryotes have shown that Hsp70 and Hsp40/Hdj1 family proteins are sufficient to prevent protein misfolding and aggregation and to promote refolding of denatured polypeptides. Additional protein cofactors include Hip and Bag1, identified in protein interaction assays, which bind to and modulate Hsp70 chaperone activity in vitro. Bag1, originally identified as an...

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PMID: 10629065
DOI: 10.1128/mcb.20.3.1083-1088.2000

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