Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway.

Cancer research - 15 Jul 2003

Townsend Paul A, Cutress Ramsey I, Sharp Adam, Brimmell Matthew, Packham Graham

Abstract excerpt

BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been studied in detail. Here we demonstrate that BAG-1 overexpression completely protected breast cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Chaperones

Share to Protein Isoforms

Share to Stress, Physiological

Share to TNF-Related Apoptosis-Inducing Ligand

Share to Tumor Cells, Cultured

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 12874020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway.PMID 12874020Read ↗

Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.Semantic proximity Read ↗

Bag1 Functions In Vivo as a Negative Regulator of Hsp70 Chaperone ActivitySemantic proximity Read ↗

HSP70s in Breast Cancer: Promoters of Tumorigenesis and Potential Targets/Tools for TherapySemantic proximity Read ↗

Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.Semantic proximity Read ↗

BAG-1 diversely affects steroid receptor activity.Semantic proximity Read ↗

Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein.Semantic proximity Read ↗

Heat Shock Proteins Promote Cancer: It's a Protection Racket.Semantic proximity Read ↗

Heat shock proteins in cancer: chaperones of tumorigenesis.Semantic proximity Read ↗

The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in CancerSemantic proximity Read ↗

Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells.Semantic proximity Read ↗

Origin and Evolution of the Human Bcl2-Associated Athanogene-1 (BAG-1).Semantic proximity Read ↗

Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.