Article

Up-regulation of Grb2-associated binder 1 promotes hepatocyte growth factor induced endothelial progenitor cell proliferation and migration

2018-12-07

Abstract excerpt

<h4>Objectives: </h4> . Grb2-associated binder 1 (Gab1), a scaffolding adaptor protein, plays an important role in transmitting key signals that control cell growth, migration, and function from multiple tyrosine kinase receptors. This study was designed to investigate the influence of upregulation of Gab1 in endothelial progenitor cells (EPCs) stimulated with hepatocyte growth factor (HGF), and the underlying mol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 21846656-85b3-5c07-986c-69b0d3684c6b
DOI: 10.7287/peerj.preprints.27417v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Up-regulation of Grb2-associated binder 1 promotes hepatocyte growth factor induced endothelial progenitor cell proliferation and migrationDOI 10.7287/peerj.preprints.27417v1Read

Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation.Semantic proximity Read

Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Semantic proximity Read

The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase.Semantic proximity Read

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.Semantic proximity Read

The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair.Semantic proximity Read

Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis.Semantic proximity Read

Distinct requirements for Gab1 in Met and EGF receptor signaling <i>in vivo</i>Semantic proximity Read

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.Semantic proximity Read

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.Semantic proximity Read

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Semantic proximity Read

Gene of the month: <i>HGF</i>Semantic proximity Read

microRNA-302c-3p inhibits renal cell carcinoma cell proliferation by targeting Grb2-associated binding 2 (Gab2)Semantic proximity Read