Article
Molecular characteristics of HGF and the gene, and its biochemical aspects.
EXS - 1 Jan 1993
Mizuno K, Nakamura T
Abstract excerpt
Hepatocyte growth factor (HGF) was initially identified as a potent mitogen for mature hepatocytes in sera of partially hepatectomized rats and seems to be the long sought after hepatotrophic factor for liver regeneration. HGF, first purified to homogeneity from rat platelets in 1986, is a disulfide-linked heterodimer molecule composed of a 69 kDa alpha-subunit and a 34 kDa beta-subunit. In 1989, cDNAs of both...
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