Article
Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.
FEBS letters - 3 Nov 2009
Sharp Adam, Cutress Ramsey I, Johnson Peter W M, Packham Graham, Townsend Paul A
Abstract excerpt
BAG-1, a multifunctional protein, interacts with a plethora of cellular targets where the interaction with HSC70 and HSP70, is considered vital. Structural studies have demonstrated the C-terminal of BAG-1 forms a bundle of three alpha-helices of which helices 2 and 3 are directly involved in bin...
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