Article
BAG-1 diversely affects steroid receptor activity.
The Biochemical journal - 1 Jan 2012
Knapp Regina T, Steiner Andrea, Schmidt Ulrike, Hafner Kathrin, Holsboer Florian, Rein Theo
Abstract excerpt
Part of the cellular and physiological functions of BAG-1 (Bcl-2-associated athanogene 1) has been ascribed to the ability of this hsp70 (heat-shock protein 70) co-chaperone to regulate steroid receptor activity. BAG-1 has been reported to inhibit the GR (glucocorticoid receptor) and stimulate the androgen receptor, but to leave the activity of the MR (mineralocorticoid receptor) unchanged. Given the high...
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